*PAD=peripheral artery disease.

What is XARELTO®?

XARELTO® belongs to a group of medicines called direct oral anticoagulants, or DOACs for short. Like other DOACs, XARELTO® has no known dietary restrictions and no requirements for frequent blood tests.

Risk factors image

Taking XARELTO® with low-dose aspirin helps to reduce your risk of a sudden decrease in blood flow to the legs, major amputation, serious heart problems, or stroke.

85%

In fact, in a clinical trial, almost 85% of adults who took XARELTO®, in combination with low-dose aspirin,† did not have a heart attack, stroke, sudden decrease in blood flow in the legs, or amputation after vascular intervention.‡

95%

And, in another clinical trial, almost 95% of adults with chronic PAD taking XARELTO® 2.5 mg twice daily, in combination with low-dose aspirin,† did not have a heart attack, stroke, or die from a cardiovascular event.§

Remember, all blood thinners come with a risk of bleeding. In a clinical trial, less than 2% of people taking XARELTO® 2.5 mg twice daily in combination with low-dose aspirin experienced a major bleeding event, such as bleeding into the brain. And, in another clinical trial, around 3% of people taking XARELTO®, in combination with aspirin, experienced a major bleeding event versus 1% of people taking only low-dose aspirin. That represents about a 1% increase in bleeding versus people taking only low-dose aspirin.

†Low-dose aspirin = 75 mg–100 mg once daily.

‡XARELTO®, in combination with aspirin, reduced the rate of stroke, heart attack, poor blood flow in the legs, and amputation vs aspirin alone (15.5% vs 17.8%). Patients were followed for an average length of treatment of 30 months.

§The rate of the first event like a stroke, heart attack, or cardiovascular death was 5.1% for people taking XARELTO® plus aspirin vs 6.9% for aspirin alone. Patients were followed for an average of 23 months.

Pad Talk to your doctor

Talk to your doctor about XARELTO®

Use this guide to discuss the risks of cardiac events due to PAD with your doctor, and whether XARELTO® may be right for you.

Start a Doctor Discussion Guide

Take one XARELTO® 2.5 mg tablet twice daily with or without food in combination with low-dose aspirin (75 mg-100 mg) once daily

Tablet

Tablets shown not actual size

How do you take XARELTO®?

  • Take XARELTO® 2.5 mg twice daily with or without food in combination with aspirin 75 mg–100 mg once daily as instructed by your healthcare professional.
  • If you miss a dose of XARELTO®, take your next 2.5 mg dose at your regularly scheduled time.
  • Remember, there are no known dietary restrictions, unlike warfarin (Coumadin®).

Are there any side effects associated with XARELTO® in adults?

Side effects of XARELTO®:

  • Increased risk of bleeding
    • You are likely to bruise more easily and it may take longer for the bleeding to stop

Your risk of bleeding increases if you take XARELTO® with other medicines that also increase your risk of bleeding, such as:

    • Aspirin or aspirin-containing products
    • Long-term (chronic) use of non-steroidal anti-inflammatory drugs (NSAIDs)
    • Warfarin sodium (Coumadin®, Jantoven®)
    • Any medicine that contains heparin
    • Clopidogrel (Plavix®)
    • Selective serotonin reuptake inhibitors (SSRIs)
    • Serotonin norepinephrine reuptake inhibitors (SNRIs)
    • Other medicines to prevent or treat blood clots

Always tell your healthcare professional if you experience any side effects while taking
XARELTO® —keeping an open and honest conversation going with your healthcare professional may help you get the best care. You can use the Doctor Discussion Guide to help inform your conversation.