*PAD=peripheral artery disease.
What is XARELTO® ?
XARELTO® belongs to a group of medicines called direct oral anticoagulants, or DOACs for short. Like other DOACs, XARELTO® has no known dietary restrictions and no requirements for frequent blood tests.
Taking XARELTO® with low-dose aspirin helps to reduce your risk of a sudden decrease in blood flow to the legs, major amputation, serious heart problems, or stroke.
In fact, in a clinical trial, almost 85% of adults who took XARELTO®, in combination with low-dose aspirin,† did not have a heart attack, stroke, sudden decrease in blood flow in the legs, or amputation after vascular intervention.‡
And, in another clinical trial, almost 95% of adults with chronic PAD taking XARELTO® 2.5 mg twice daily, in combination with low-dose aspirin,† did not have a heart attack, stroke, or die from a cardiovascular event.§
Remember, all blood thinners come with a risk of bleeding. In a clinical trial, less than 2% of people taking XARELTO® 2.5 mg twice daily in combination with low-dose aspirin experienced a major bleeding event, such as bleeding into the brain.
And, in another clinical trial, around 3% of people taking XARELTO®, in combination with aspirin, experienced a major bleeding event versus 1% of people taking only low-dose aspirin. That represents about a 1% increase in bleeding versus people taking only low-dose aspirin.
†Low-dose aspirin = 75 mg–100 mg once daily.
‡XARELTO®, in combination with aspirin, reduced the rate of stroke, heart attack, poor blood flow in the legs, and amputation vs aspirin alone (15.5% vs 17.8%). Patients were followed for an average length of treatment of 30 months.
§The rate of the first event like a stroke, heart attack, or cardiovascular death was 5.1% for people taking XARELTO® plus aspirin vs 6.9% for aspirin alone. Patients were followed for an average of 23 months.
Talk to your doctor about XARELTO®
Use this guide to discuss the risks of cardiac events due to PAD with your doctor, and whether XARELTO® may be right for you.
Take one XARELTO® 2.5 mg tablet twice daily with or without food in combination with low-dose aspirin (75 mg-100 mg) once daily
Tablets shown not actual size
How do you take XARELTO®?
- Take XARELTO® 2.5 mg twice daily with or without food in combination with aspirin 75 mg–100 mg once daily as instructed by your healthcare professional.
- If you miss a dose of XARELTO®, take your next 2.5 mg dose at your regularly scheduled time.
- Remember, there are no known dietary restrictions, unlike warfarin (Coumadin®).
Are there any side effects associated with XARELTO® in adults?
Side effects of XARELTO®:
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Increased risk of bleeding
- You are likely to bruise more easily and it may take longer for the bleeding to stop
Your risk of bleeding increases if you take XARELTO® with other medicines that also increase your risk of bleeding, such as:
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- Aspirin or aspirin-containing products
- Long-term (chronic) use of non-steroidal anti-inflammatory drugs (NSAIDs)
- Warfarin sodium (Coumadin®, Jantoven®)
- Any medicine that contains heparin
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- Clopidogrel (Plavix®)
- Selective serotonin reuptake inhibitors (SSRIs)
- Serotonin norepinephrine reuptake inhibitors (SNRIs)
- Other medicines to prevent or treat blood clots
Always tell your healthcare professional if you experience any side effects while taking XARELTO®—keeping an open and honest conversation going with your healthcare professional may help you get the best care. You can use the Doctor Discussion Guide to help inform your conversation.
Getting started with XARELTO®?
Discover information about getting started with XARELTO®, savings options, and your condition—all in one helpful starter kit.